Application of genetic screening information to the management of medullary thyroid carcinoma and multiple endocrine neoplasia type 2

被引：47

作者：

Wohllk, N

Cote, GJ

Evans, DB

Goepfert, H

Ordonez, NG

Gagel, RF

机构：

[1] UNIV TEXAS, MD ANDERSON CANCER CTR, ENDOCRINOL SECT, HOUSTON, TX 77030 USA

[2] UNIV TEXAS, MD ANDERSON CANCER CTR, DIV SURG, HOUSTON, TX 77030 USA

[3] UNIV TEXAS, MD ANDERSON CANCER CTR, DIV PATHOL, HOUSTON, TX 77030 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 1996年 / 25卷 / 01期

关键词：

CHRONIC LYMPHOCYTIC THYROIDITIS; C-CELL HYPERPLASIA; RET PROTOONCOGENE; EARLY DIAGNOSIS; NEURAL CREST; ACTIVATION; CHILDREN; ONCOGENE; GLAND; CHROMOSOME-10;

D O I：

10.1016/S0889-8529(05)70310-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The discovery of RET proto-oncogene mutations causative for multiple endocrine neoplasia type 2 and familial medullary thyroid carcinoma now makes it possible to identify gene carriers with a high degree of certainty. The correct application of this information, however, requires an understanding of the specific mutations and the associated clinical syndromes. This review provides a synopsis of current trends in this field and their application to the clinical management of hereditary and sporadic medullary thyroid carcinoma.

引用

页码：1 / +

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