Amidine derived 1,3-diazabuta-1,3-dienes as potential antibacterial and antifungal agents

被引：14

作者：

Bedi, PMS ^{[1
]}

Mahajan, MP

Kapoor, VK

机构：

[1] Guru Nanak Dev Univ, Dept Pharmaceut Sci, Amritsar 143005, Punjab, India

[2] Guru Nanak Dev Univ, Dept Appl Chem, Amritsar 143005, Punjab, India

[3] Panjab Univ, Univ Inst Pharmaceut Sci, Chandigarh 160014, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 14期

关键词：

D O I：

10.1016/j.bmcl.2004.04.104

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several 1-aryl-2-phenyl-4-piperidino-4-thioalkyl-1,3-diazabuta-1,3-dienes were prepared by the treatment of N-arylimino isothiocyanate with piperidine followed by S-alkylation with alkyl iodides in the presence of dry acetone and potassium hydroxide. The constitution of the products was supported by IR, PMR and mass spectral study. The compounds synthesized were tested in in vitro against E coli, S. aureus, P. aeruginosa, B. cereus and B. subtilis and fungal stains, Candida albicans and Aspergillus niger. Standard drugs were also tested under identical conditions for comparing the results. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3821 / 3824

页数：4

共 22 条

[1] Structure-based drug design [J].

Amzel, LM .

CURRENT OPINION IN BIOTECHNOLOGY, 1998, 9 (04) :366-369

[2]

Bedi PMS, 2003, PDA J PHARM SCI TECH, V57, P109

[3]

BEDI PMS, 2004, INDIAN J PHARM SCI, V66, P112

[4] N'-SUBSTITUTED N-ACYL-THIOUREAS AND N-IMIDOYL-THIOUREAS - PREPARATION AND CONVERSION OF N',N'-DISUBSTITUTED COMPOUNDS INTO 2-(N,N-DISUBSTITUTED AMINO)THIAZOL-5-YL KETONES [J].

BRINDLEY, JC ;

CALDWELL, JM ;

MEAKINS, GD ;

PLACKETT, SJ ;

PRICE, SJ .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1987, (05) :1153-1158

[5] CRYSTAL-STRUCTURE OF A BERENIL-D(CGCAAATTTGCG) COMPLEX - AN EXAMPLE OF DRUG DNA RECOGNITION BASED ON SEQUENCE-DEPENDENT STRUCTURAL FEATURES [J].

BROWN, DG ;

SANDERSON, MR ;

GARMAN, E ;

NEIDLE, S .

JOURNAL OF MOLECULAR BIOLOGY, 1992, 226 (02) :481-490

[6] CRYSTAL-STRUCTURE OF A BERENIL DODECANUCLEOTIDE COMPLEX - THE ROLE OF WATER IN SEQUENCE-SPECIFIC LIGAND-BINDING [J].

BROWN, DG ;

SANDERSON, MR ;

SKELLY, JV ;

JENKINS, TC ;

BROWN, T ;

GARMAN, E ;

STUART, DI ;

NEIDLE, S .

EMBO JOURNAL, 1990, 9 (04) :1329-1334

[7] SYNTHESIS AND REGIOSELECTIVE [4+2] CYCLOADDITION NUCLEOPHILIC REACTIONS OF N-ARYLAMINO-1,3-DIAZA-1,3-BUTADIENES WITH KETENES AND ACCOMPANYING REARRANGEMENTS [J].

DEY, PD ;

SHARMA, AK ;

RAI, SN ;

MAHAJAN, MP .

TETRAHEDRON, 1995, 51 (27) :7459-7468

[8] CRYSTAL-STRUCTURE OF A PENTAMIDINE OLIGONUCLEOTIDE COMPLEX - IMPLICATIONS FOR DNA-BINDING PROPERTIES [J].

EDWARDS, KJ ;

JENKINS, TC ;

NEIDLE, S .

BIOCHEMISTRY, 1992, 31 (31) :7104-7109

[9] FOOTPRINTING STUDIES ON THE SEQUENCE-SELECTIVE BINDING OF PENTAMIDINE TO DNA [J].

FOX, KR ;

SANSOM, CE ;

STEVENS, MFG .

FEBS LETTERS, 1990, 266 (1-2) :150-154

[10]

Greenhill J V, 1993, Prog Med Chem, V30, P203, DOI 10.1016/S0079-6468(08)70378-3

← 1 2 3 →