Health promoting compounds in vegetables and fruits:: A systematic approach for identifying plant components with impact on human health

被引：100

作者：

Brandt, K

Christensen, LP

Hansen-Moller, J

Hansen, SL

Haraldsdottir, J

Jespersen, L

Purup, S

Kharazmi, A

Barkholt, V

Frokiær, H

Kobæk-Larsen, M

机构：

[1] Newcastle Univ, Sch Agr Food & Rural Dev, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[2] Danish Inst Agr Sci, Dept Food Sci, DK-5792 Aarslev, Denmark

[3] Royal Vet & Agr Univ, Dept Human Nutr, DK-1958 Frederiksberg C, Denmark

[4] Danish Inst Agr Sci, Dept Anim Physiol & Nutr, Res Ctr Foulum, DK-8830 Tjele, Denmark

[5] Univ Copenhagen Hosp, Dept Clin Microbiol, DK-2200 Copenhagen N, Denmark

[6] Tech Univ Denmark, Bioctr, DK-2800 Lyngby, Denmark

[7] Univ So Denmark, Biomed Lab, DK-5000 Odense C, Denmark

来源：

TRENDS IN FOOD SCIENCE & TECHNOLOGY | 2004年 / 15卷 / 7-8期

关键词：

D O I：

10.1016/j.tifs.2003.12.003

中图分类号：

TS2 [食品工业];

学科分类号：

0832 [食品科学与工程];

摘要：

Vegetables contain unknown compounds with important health promoting effect. The described project defined and tested a two-step screening procedure for identification of such compounds. Step 1 is initial screening according to three criteria: 1.1, chemically reactive functional groups; 1.2, toxicity at high concentrations or other bioactivity; and 1.3, presence in healthy foods. Step 2 is testing for minimum criteria defining health-promoting compounds: 2.1, positive or biphasic ("hormesis") responses in bioassay; 2.2, human tissue concentrations corresponding to beneficial effects in bioassay; and 2.3, possibility to control content in food. Falcarinol from carrots fulfilled all 6 criteria and subsequently showed anticancer effect in rats. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：384 / 393

页数：10

共 60 条

[1]

Consumption of vegetables, fruit and other plant foods in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohorts from 10 European countries [J].