U87 RNA, a novel C/D box small nucleolar RNA from mammalian cells

被引：14

作者：

Gogolevskaya, IK

Makarova, JA

Gause, LN

Kulichkova, VA

Konstantinova, IM

Kramerov, DA

机构：

[1] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 119991, Russia

[2] Russian Acad Sci, NK Koltsov Dev Biol Inst, Moscow 117808, Russia

[3] Russian Acad Sci, Inst Cytol, St Petersburg 194064, Russia

来源：

GENE | 2002年 / 292卷 / 1-2期

基金：

俄罗斯基础研究基金会;

关键词：

rodents; alpha-ribonucleoprotein; low-molecular weight RNA; small nucleolar RNA gene; RNA processing; ribosomal RNA methylation; terminal stem;

D O I：

10.1016/S0378-1119(02)00678-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A novel 72 nt small nucleolar RNA (snoRNA) called U87 was found in rat liver cells. This RNA possesses the features of C/D box snoRNA family: boxes C, D', C, D, and 11 nt antisense element complementary to 28S ribosomal RNA (rRNA). The vast majority of CID box snoRNAs direct site-specific 2'-O-ribose methylation of rRNAs. U87 RNA is suggested to be involved in 2'-O-methylation of a G(3468) residue in 28S rRNA. U87 RNA was detected in different mammalian species with slight length variability. Rat and mouse U87 RNA gene was characterized. Unlike the majority of C/D box snoRNAs U87 RNA lacks the terminal stem required for snoRNA processing. However, U87 gene is flanked by 7 bp inverted repeats potentially able to form a terminal stem in U87 RNA precursor. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：199 / 204

页数：6

共 30 条

[1] Guiding ribose methylation of rRNA [J].