Solution-phase parallel synthesis of substituted benzimidazoles

被引：24

作者：

Raju, B ^{[1
]}

Nguyen, N ^{[1
]}

Holland, GW ^{[1
]}

机构：

[1] Texas Biotechnol Corp, Dept Chem & Biophys, Houston, TX 77030 USA

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2002年 / 4卷 / 04期

关键词：

D O I：

10.1021/cc000098d

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A solution-phase parallel synthesis of o-phenylenediamines is described. These intermediates were then subsequently converted to benzimidazole scaffolds (three-point diversity) in excellent purities and yields. High-throughput purification of this multistep synthetic sequence was accomplished using polymer-bound scavengers and reagents and liquid-liquid extraction protocols.

引用

页码：320 / 328

页数：9

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