Structural basis for peptidomimicry by the effector element of rapamycin

被引:14
作者
Odagaki, Y [1 ]
Clardy, J [1 ]
机构
[1] CORNELL UNIV,BAKER LAB,DEPT CHEM,ITHACA,NY 14853
关键词
D O I
10.1021/ja972098w
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:10253 / 10254
页数:2
相关论文
共 23 条
[1]   SUBSTRATE-SPECIFICITY FOR THE HUMAN ROTAMASE FKBP - A VIEW OF FK506 AND RAPAMYCIN AS LEUCINE (TWISTED AMIDE) PROLINE MIMICS [J].
ALBERS, MW ;
WALSH, CT ;
SCHREIBER, SL .
JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (17) :4984-4986
[2]   Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: Tacrolimus (FK506), sirolimus (rapamycin), mycophenolate mofetil and leflunomide [J].
Brazelton, TR ;
Morris, RE .
CURRENT OPINION IN IMMUNOLOGY, 1996, 8 (05) :710-720
[3]   A MAMMALIAN PROTEIN TARGETED BY G1-ARRESTING RAPAMYCIN-RECEPTOR COMPLEX [J].
BROWN, EJ ;
ALBERS, MW ;
SHIN, TB ;
ICHIKAWA, K ;
KEITH, CT ;
LANE, WS ;
SCHREIBER, SL .
NATURE, 1994, 369 (6483) :756-758
[4]  
Brunger A.T., 1992, X PLOR VERSION 3 1 M
[5]   Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002 [J].
Brunn, GJ ;
Williams, J ;
Sabers, C ;
Wiederrecht, G ;
Lawrence, JC ;
Abraham, RT .
EMBO JOURNAL, 1996, 15 (19) :5256-5267
[6]   FKBP-12 recognition is dispensable for signal generation by type I transforming growth factor-beta receptors [J].
Charng, MJ ;
Kinnunen, P ;
Hawker, J ;
Brand, T ;
Schneider, MD .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (38) :22941-22944
[7]   IDENTIFICATION OF AN 11-KDA FKBP12-RAPAMYCIN-BINDING DOMAIN WITHIN THE 289-KDA FKBP12-RAPAMYCIN-ASSOCIATED PROTEIN AND CHARACTERIZATION OF A CRITICAL SERINE RESIDUE [J].
CHEN, J ;
ZHENG, XF ;
BROWN, EJ ;
SCHREIBER, SL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (11) :4947-4951
[8]   Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP [J].
Choi, JW ;
Chen, J ;
Schreiber, SL ;
Clardy, J .
SCIENCE, 1996, 273 (5272) :239-242
[9]   WHEN IS A LIPID KINASE NOT A LIPID KINASE - WHEN IT IS A PROTEIN-KINASE [J].
HUNTER, T .
CELL, 1995, 83 (01) :1-4
[10]   STRUCTURAL BASIS FOR PEPTIDOMIMICRY BY A NATURAL PRODUCT [J].
IKEDA, Y ;
SCHULTZ, LW ;
CLARDY, J ;
SCHREIBER, SL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (09) :4143-4144