Synthesis and anticancer activity of side chain analogs of the crambescidin alkaloids

被引：28

作者：

Aron, ZD

Pietraszkiewicz, H

Overman, LE

Valeriote, F

Cuevas, C

机构：

[1] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA

[2] Josephine Ford Canc Ctr, Detroit, MI 48202 USA

[3] Pharma Mar SA, Madrid 28770, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 13期

关键词：

D O I：

10.1016/j.bmcl.2004.04.071

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Twenty three side chain analogs of the crambescidin alkaloids were prepared from the corresponding pentacyclic zwitterionic core acid. In the crambescidin 800 and 657 series, potency increased with increasing chain length. In addition, substantial variations in tumor selectivity with structure were seen. Crambescidin analogs having short, nonpolar side chains were identified for the first time as promising anticancer agents. (C) 2004 Elsevier Ltd. All rights reserved.

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收藏

页码：3445 / 3449

页数：5

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