GERD Symptoms in the General Population: Prevalence and Severity Versus Care-Seeking Patients

被引:39
作者
Cohen, Erica [1 ,2 ]
Bolus, Roger [3 ,4 ]
Khanna, Dinesh [5 ]
Hays, Ron D. [6 ,7 ]
Chang, Lin [3 ,8 ]
Melmed, Gil Y. [2 ]
Khanna, Puja [5 ]
Spiegel, Brennan [1 ,3 ,4 ]
机构
[1] VA Greater Los Angeles Healthcare Syst, Dept Gastroenterol, Los Angeles, CA 90073 USA
[2] Cedars Sinai Med Ctr, Dept Gastroenterol, West Hollywood, CA USA
[3] Univ Calif Los Angeles, David Geffen Sch Med, Div Digest Dis, Los Angeles, CA 90095 USA
[4] UCLA VA Ctr Outcomes Res & Educ, Los Angeles, CA USA
[5] Univ Michigan, Div Rheumatol, Ann Arbor, MI 48109 USA
[6] Univ Calif Los Angeles, David Geffen Sch Med, Div Gen Internal Med & Hlth Serv Res, Los Angeles, CA 90095 USA
[7] UCLA Sch Publ Hlth, Dept Hlth Serv, Los Angeles, CA USA
[8] Univ Calif Los Angeles, David Geffen Sch Med, Ctr Neurobiol Stress, Los Angeles, CA 90095 USA
基金
美国国家卫生研究院;
关键词
Gastroesophageal reflux disease; Patient-reported outcomes; Symptoms; GASTROESOPHAGEAL-REFLUX DISEASE; IRRITABLE-BOWEL-SYNDROME; QUALITY-OF-LIFE; VISCERAL SENSITIVITY INDEX; REPORTED OUTCOMES; UNITED-STATES; EPIDEMIOLOGY; DISORDERS; BURDEN; VALIDATION;
D O I
10.1007/s10620-014-3181-8
中图分类号
R57 [消化系及腹部疾病];
学科分类号
100201 [内科学];
摘要
Prior estimates suggest that up to 40 % of the US general population (GP) report symptoms of gastroesophageal reflux disease (GERD). However, symptoms in the GP versus patients seeking care for gastrointestinal (GI) complaints have not been compared. We estimated the prevalence and severity of GERD symptoms in the GP versus GI patients, and identified predictors of GERD severity. We hypothesized that similar to functional GI disorders, psychosocial factors would predict symptom severity in GERD as much, or perhaps more, than care-seeking behavior alone. We compared the prevalence of heartburn and regurgitation between a sample from the US GP and patients seeking GI specialty care. We compared GERD severity between groups using the NIH PROMISA (R) GERD scale. We then performed multivariable regression to identify predictors of GERD severity. There was no difference in the prevalence of heartburn between the GP and patient groups (59 vs. 59 %), but regurgitation was more common in patients versus GP (46 vs. 39 %; p = 0.004). In multivariable regression, having high visceral anxiety (p < 0.001) and being divorced or separated (p = 0.006) were associated with higher GERD severity. More than half of a GP sample reports heartburn-higher than previous series and no different from GI patients. Although regurgitation was more prevalent in patients versus the GP, there was no difference in GERD severity between groups after adjusting for other factors; care seeking in GERD appears related to factors beyond symptoms, including visceral anxiety.
引用
收藏
页码:2488 / 2496
页数:9
相关论文
共 33 条
[1]
Agréus L, 2001, AM J GASTROENTEROL, V96, P2905
[2]
BAKER LH, 1995, AM J GASTROENTEROL, V90, P1797
[3]
Systematic review: the association between symptomatic response to proton pump inhibitors and health-related quality of life in patients with gastro-oesophageal reflux disease [J].
Becher, A. ;
El-Serag, H. .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2011, 34 (06) :618-627
[4]
Comparative study of characteristics and disease management between subjects with frequent and occasional gastro-oesophageal reflux symptoms [J].
Bretagne, JF ;
Honnorat, C ;
Richard-Molard, B ;
Caekaert, A ;
Barthélemys, P .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2006, 23 (05) :607-616
[5]
Prevalence and socioeconomic impact of upper gastrointestinal disorders in the United States: Results of the US upper gastrointestinal study [J].
Camilleri, M ;
Dubois, D ;
Coulie, B ;
Jones, M ;
Kahrilas, PJ ;
Rentz, AM ;
Sonnenberg, A ;
Stanghellini, V ;
Stewart, WF ;
Tack, J ;
Talley, NJ ;
Whitehead, W ;
Revicki, DA .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2005, 3 (06) :543-552
[6]
The Patient-Reported Outcomes Measurement Information System (PROMIS) Progress of an NIH roadmap cooperative group during its first two years [J].
Cella, David ;
Yount, Susan ;
Rothrock, Nan ;
Gershon, Richard ;
Cook, Karon ;
Reeve, Bryce ;
Ader, Deborah ;
Fries, James F. ;
Bruce, Bonnie ;
Rose, Mattias .
MEDICAL CARE, 2007, 45 (05) :S3-S11
[8]
Epidemiology of gastrooesophageal reflux disease: A systematic review [J].
Dent, J ;
El-Serag, HB ;
Wallander, MA ;
Johansson, S .
GUT, 2005, 54 (05) :710-717
[9]
Evaluation of item candidates - The PROMIS qualitative item review [J].
DeWalt, Darren A. ;
Rothrock, Nan ;
Yount, Susan ;
Stone, Arthur A. .
MEDICAL CARE, 2007, 45 (05) :S12-S21
[10]
Systematic review: the epidemiology of gastro-oesophageal reflux disease in primary care, using the UK General Practice Research Database [J].
El-Serag, H. ;
Hill, C. ;
Jones, R. .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2009, 29 (05) :470-480