Synthesis of ansa-bridged macrocyclic lactams related to the antitumor antibiotic geldanamycin by ring closing metathesis

被引：26

作者：

Bach, T ^{[1
]}

Lemarchand, A ^{[1
]}

机构：

[1] Tech Univ Munich, Lehrstuhl Organ Chem 1, D-85747 Garching, Germany

来源：

SYNLETT | 2002年 / 08期

关键词：

arenes; antitumor agents; macrocycles; metathesis; ring closure;

D O I：

10.1055/s-2002-32958

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The alpha,beta,gamma,delta-unsaturated 2,4,5-trimethoxyanilides 8a-e which bear a terminal alkenyl side chain at the 3-position were prepared from 1,2,4-trimethoxybenzene (2) in four step, and 25-41% overall yield. Attempted ring closing metathesis reactions were successful in the presence of catalysts 9 for the substrates 8c-e and led to the products 10c-e (66-91% yield). Substrates Sa and 8b with a shorter alkenyl side chain did not cyclize.

引用

页码：1302 / 1304

页数：3

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