Decoding cis-regulatory DNAs in the Drosophila genome

被引：45

作者：

Markstein, M

Levine, M

机构：

[1] Univ Calif Berkeley, Dept Mol Cell Biol, Div Genet & Dev, Berkeley, CA 94720 USA

[2] Univ Chicago, Cummings Life Sci Ctr, Comm Dev Biol, Chicago, IL 60637 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2002年 / 12卷 / 05期

关键词：

D O I：

10.1016/S0959-437X(02)00345-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cis-regulatory DNAs control the timing and sites of gene expression during metazoan development. Changes in gene expression are responsible for the morphological diversification of metazoan body plans. However, traditional methods for the identification and characterization of cis-regulatory DNAs are tedious. During the past year, computational methods have been used to identify novel cis-DNAs within the entire Drosophila genome. These methods change the way that cis-DNAs will be analyzed in future studies and offer the promise of unraveling complex gene networks.

引用

页码：601 / 606

页数：6

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