Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation

被引：235

作者：

van Bezooijen, Rutger L. ^{[1
]}

Svensson, J. Peters

Eefting, Daniel

Visser, Annemieke

van der Horst, Geertje

Karperien, Marcel

Quax, Paul H. A.

Vrieling, Harry

Papapoulos, Socrates E.

ten Dijke, Peter

Lowik, Clemens W. G. M.

机构：

[1] Leiden Univ, Med Ctr, Dept Endocrinol, NL-2300 RA Leiden, Netherlands

[2] Leiden Univ, Med Ctr, Dept Metab Dis, NL-2300 RA Leiden, Netherlands

[3] Leiden Univ, Med Ctr, Dept Mol Cell Biol, NL-2300 RA Leiden, Netherlands

[4] Leiden Univ, Med Ctr, Dept Toxicogenet, NL-2300 RA Leiden, Netherlands

[5] Uppsala Univ, Univ Hosp, Dept Oncol Radiol & Clin Immunol, S-75105 Uppsala, Sweden

[6] TNO Qual Life, Gaubius Lab, NL-2300 AK Leiden, Netherlands

[7] Leiden Univ, Med Ctr, Dept Urol, NL-2300 RA Leiden, Netherlands

[8] Leiden Univ, Med Ctr, Dept Pediat, NL-2300 RA Leiden, Netherlands

[9] Leiden Univ, Med Ctr, Dept Surg, NL-2300 RA Leiden, Netherlands

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 01期

关键词：

sclerostin; SOST; Wnt; BMP; signal transduction; bone formation; microarray;

D O I：

10.1359/JBMR.061002

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Sclerostin is an osteocyte-derived negative regulator of bone formation. It inhibits BMP-stimulated bone formation both in vitro and in vivo but has no direct effect on BMP signaling. Instead, sclerostin inhibits Writ signaling that is required for BMP-stimulated osteoblastic differentiation.

引用

页码：19 / 28

页数：10

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