Effectiveness and tolerance of anti-inflammatory drugs' add-on therapy in major mental disorders: a systematic qualitative review

被引：134

作者：

Fond, G. ^{[1
]}

Hamdani, N. ^{[1
]}

Kapczinski, F. ^{[2
,3
]}

Boukouaci, W. ^{[4
,5
]}

Drancourt, N. ^{[1
]}

Dargel, A. ^{[2
,3
,4
]}

Oliveira, J. ^{[4
,5
]}

Le Guen, E. ^{[1
]}

Marlinge, E. ^{[1
]}

Tamouza, R. ^{[4
,5
]}

Leboyer, M. ^{[1
]}

机构：

[1] Univ Paris Est Creteil, INSERM, U955, Fdn Fondamental Fdn Cooperat Sci Sante Mentale, Creteil, France

[2] Hosp Clin Porto Alegre, Ctr Pesquisas Expt, Lab Mol Psychiat, Porto Alegre, RS, Brazil

[3] INCT Translat Med, Porto Alegre, RS, Brazil

[4] Hop St Louis, Jean Dausset Lab, Paris, France

[5] Hop St Louis, INSERM, UMRS 940, Paris, France

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 2014年 / 129卷 / 03期

关键词：

anti-inflammatory; cyclooxygenase-1; cyclooxygenase-2; non-steroidal anti-inflammatory drugs; celecoxib; salicylate; tumor necrosis factor; infliximab; minocycline; depression; schizophrenia; bipolar disorders; POLYUNSATURATED FATTY-ACIDS; SUPPLEMENTATION LOWERS INFLAMMATION; PLACEBO-CONTROLLED TRIALS; PROSTATE-CANCER RISK; DOUBLE-BLIND; BIPOLAR DISORDER; TNF-ALPHA; DEPRESSIVE DISORDER; ADJUNCTIVE THERAPY; EICOSAPENTAENOIC ACID;

D O I：

10.1111/acps.12211

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

ObjectiveTo provide a systematic review of the literature regarding the efficacy of anti-inflammatory drugs in three major mental disorders [major depressive disorder (MDD), schizophrenia and bipolar disorders]. MethodFour databases were explored, without any year or language restrictions. The baseline search paradigm was limited to open-labelled clinical and randomized controlled trials (RCTs). ResultsFour major classes of anti-inflammatory drugs were identified, namely polyunsaturated fatty acids (PUFAs), cyclooxygenase (COX) inhibitors, anti-TNFalpha and minocycline. Effectiveness and benefit/risk ratio of each class in MDD, bipolar disorders and schizophrenia was detailed when data were available. Several meta-analyses indicated effectiveness of PUFAs in MDD with a good tolerance profile. One meta-analysis indicated that COX-2 specific inhibitors showed effectiveness in schizophrenia. Anti-TNFalpha showed important effectiveness in resistant MDD with blood inflammatory abnormalities. Minocycline showed effectiveness in schizophrenia. ConclusionPolyunsaturated fatty acids seem to have the best benefit/risk ratio profile but proved their effectiveness only in MDD. A number of anti-inflammatory drugs are available as adjunct treatment for treatment-resistant patients with MDD, schizophrenia and bipolar disorder. If used with caution regarding their possible side-effects, they may be reasonable therapeutic alternatives for resistant symptomatology.

引用

页码：163 / 179

页数：17

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