How DNA microarrays and expression profiling will affect clinical practice

被引:18
作者
Friend, SH [1 ]
机构
[1] Rosetta Inpharmat, Kirkland, WA 98034 USA
关键词
D O I
10.1136/bmj.319.7220.1306
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In Plato's cave the participants ale surrounded by shadows that allow them to see reality by careful examination, Similarly, we doctors at the end of the 20th century have found many Indirect tests that allow us to follow what is happening in our patients' bodies and tells, We have learnt to cope with the fact that we cannot find drugs unless we pull proteins from those tells and develop inhibitors against them in the artificial context of a test tube, Imagine now a different world in which it would be possible simultaneously to follow many changes that were happening in tells, Imagine a doctor's office where you could take a blood sample from a patient and get an indication of where that patient's heart disease, kidney disease, and depression were plotted in a matrix, allowing us, as darters, to see both the patient's relative state of health and any predisposition for other renditions or disorders.
引用
收藏
页码:1306 / U77
页数:2
相关论文
共 5 条
[1]   Exploring the metabolic and genetic control of gene expression on a genomic scale [J].
DeRisi, JL ;
Iyer, VR ;
Brown, PO .
SCIENCE, 1997, 278 (5338) :680-686
[2]   Global response of Saccharomyces cerevisiae to an alkylating agent [J].
Jelinsky, SA ;
Samson, LD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (04) :1486-1491
[3]  
Khan J, 1998, CANCER RES, V58, P5009
[4]   Drug target validation and identification of secondary drug target effects using DNA microarrays [J].
Marton, MJ ;
DeRisi, JL ;
Bennett, HA ;
Iyer, VR ;
Meyer, MR ;
Roberts, CJ ;
Stoughton, R ;
Burchard, J ;
Slade, D ;
Dai, HY ;
Bassett, DE ;
Hartwell, LH ;
Brown, PO ;
Friend, SH .
NATURE MEDICINE, 1998, 4 (11) :1293-1301
[5]   QUANTITATIVE MONITORING OF GENE-EXPRESSION PATTERNS WITH A COMPLEMENTARY-DNA MICROARRAY [J].
SCHENA, M ;
SHALON, D ;
DAVIS, RW ;
BROWN, PO .
SCIENCE, 1995, 270 (5235) :467-470