HI: haplotype improver using paired-end short reads

被引：11

作者：

Long, Quan ^{[1
]}

MacArthur, Daniel ^{[1
]}

Ning, Zemin ^{[1
]}

Tyler-Smith, Chris ^{[1
]}

机构：

[1] Wellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England

来源：

BIOINFORMATICS | 2009年 / 25卷 / 18期

基金：

英国惠康基金;

关键词：

RECONSTRUCTION; MODEL;

D O I：

10.1093/bioinformatics/btp412

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We present a program to improve haplotype reconstruction by incorporating information from paired-end reads, and demonstrate its utility on simulated data. We find that given a fixed coverage, longer reads (implying fewer of them) are preferable.

引用

页码：2436 / 2437

页数：2

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