Trypanocidal constituents in plants 6.: Minor withanolides from the aerial parts of Physalis angulata

被引：50

作者：

Abe, Fumiko ^{[1
]}

Nagafuji, Shinya ^{[1
]}

Okawa, Masafumi ^{[1
]}

Kinjo, Junei ^{[1
]}

机构：

[1] Fukuoka Univ, Fac Pharmaceut Sci, Jonan Ku, Fukuoka 8140180, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2006年 / 54卷 / 08期

关键词：

withanolide; Physalis angulata; trypanocidal activity; Trypanosoma cruzi; Solanaceae;

D O I：

10.1248/cpb.54.1226

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Further study of the methanol extract of the aerial parts of Physalis angulata (Solanaceae) resulted in the isolation of new withanolides, designated physagulins L, M and N, together with known withanolide, physagulin D and flavonol glycoside, quercetin 3-O-rhamnosyl-(1 -> 6)-galactoside. The chemical structures of these new withanolides were elucidated by detailed spectroscopic analyses to be (20R,22R)-15 alpha-acetoxy-5 alpha,6 beta,14 beta,17 beta,27-pentahydroxy-1-oxo-witha-2, 24-dienolide, (20S,22S)-15 alpha-acetoxy-5 alpha,6 beta,14 alpha,23 beta-tetrahydroxy-1-oxo-witha-2,16,24-trienolide and (20S,22R)-15 alpha-acetoxy-5 beta,6 beta-epoxy-14 alpha-hydoxy-3 beta-methoxy-1-oxo-witha-16,24-dienolide, respectively. All these compounds showed weak trypanocidal activity against trypomastigotes, an infectious form of Trypanosoma cruzi, the etiologic agent for Chagas' disease. Withanolides obtained in the previous paper showed considerable trypanocidal activity, suggesting the structure-activity relationships.

引用

页码：1226 / 1228

页数：3

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