Controlling mRNA stability and translation with small, noncoding RNAs

被引：266

作者：

Storz, G ^{[1
]}

Opdyke, JA ^{[1
]}

Zhang, AX ^{[1
]}

机构：

[1] NICHHD, Cell Biol & Metab Branch, NIH, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2004年 / 7卷 / 02期

关键词：

D O I：

10.1016/j.mib.2004.02.015

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Recent studies have lead to the identification of more than 50 small regulatory RNAs in Escherichia coli. Only a subset of these RNAs has been characterized. However, it is clear that many of the RNAs, such as the MicF, OxyS, DsrA, Spot42 and RyhB RNAs, act by basepairing to activate or repress translation or to destabilize mRNAs. Basepairing between these regulatory RNAs and their target mRNAs requires the Sm-like Hfq protein which most likely functions as an RNA chaperone to increase RNA unfolding or local target RNA concentration. Here we summarize the physiological roles of the basepairing RNAs, examine their prevalence in bacteria and discuss unresolved questions regarding their mechanisms of action.

引用

页码：140 / 144

页数：5

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