MicroRNA-23b is an independent prognostic marker and suppresses ovarian cancer progression by targeting runt-related transcription factor-2

被引：76

作者：

Li, Weiping ^{[1
]}

Liu, Zhongyu ^{[2
]}

Chen, Li ^{[2
]}

Zhou, Li ^{[3
]}

Yao, Yuanqing ^{[1
]}

机构：

[1] Gen Hosp PLA, Dept Obstet & Gynaecol, Beijing 100853, Peoples R China

[2] Med Sch PLA, Beijing 100853, Peoples R China

[3] 477 Hosp PLA, Dept Obstet & Gynaecol, Xiangyang 441003, Peoples R China

来源：

FEBS LETTERS | 2014年 / 588卷 / 09期

关键词：

Epithelial ovarian cancer; MicroRNA-23b; Runt-related transcription factor-2; Clinicopathological feature; Overall survival; Progression-free survival; HUMAN HEPATOCELLULAR-CARCINOMA; CELL-GROWTH; INVASION; CHEMORESISTANCE; MIGRATION; DIAGNOSIS; RISK;

D O I：

10.1016/j.febslet.2014.02.055

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Our previous study found that runt-related transcription factor-2 (RUNX2) was upregulated in human epithelial ovarian cancer (EOC) tissues and may be involved in tumor progression and prognosis. The aim of this study was to investigate the mechanism by which RUNX2 is aberrantly expressed in EOC. We firstly confirmed that miRNA-23b directly targets RUNX2 in EOC. Then, ectopic expression of miR-23b significantly inhibited ovarian cancer cell proliferation and tumorigenicity by regulating the expression of RUNX2. Furthermore, the down-regulation of miR-23b was significantly correlated with tumor aggressiveness and poor prognosis of patients with EOC. Collectively, miR-23b may function as tumor suppressor through inhibiting the upregulation of RUNX2, and may be a potential prognostic marker for EOC. (C) 2014 Published by Elsevier B. V. on behalf of the Federation of European Biochemical Societies.

引用

页码：1608 / 1615

页数：8

共 30 条

[1]

Regulation of breast cancer metastasis by Runx2 and estrogen signaling: the role of SNAI2 [J].

Chimge, Nyam-Osor ;

Baniwal, Sanjeev K. ;

Little, Gillian H. ;

Chen, Yi-bu ;

Kahn, Michael ;

Tripathy, Debu ;

Borok, Zea ;

Frenkel, Baruch .

BREAST CANCER RESEARCH, 2011, 13 (06)

[2]

The Role of microRNAs in the Tumorigenesis of Ovarian Cancer [J].

Di Leva, Gianpiero ;

Croce, Carlo M. .

FRONTIERS IN ONCOLOGY, 2013, 3

[3]

MicroRNAs in Human Cancer [J].

Farazi, Thalia A. ;

Hoell, Jessica I. ;

Morozov, Pavel ;

Tuschl, Thomas .

MICRORNA CANCER REGULATION: ADVANCED CONCEPTS, BIOINFORMATICS AND SYSTEMS BIOLOGY TOOLS, 2013, 774 :1-20

[4]

Fung-Kee-Fung M, 2007, Curr Oncol, V14, P195

[5]

MicroRNA-23b downregulates peroxiredoxin III in human prostate cancer [J].

He, Hui-chan ;

Zhu, Jian-guo ;

Chen, Xi-bin ;

Chen, Shan-ming ;

Han, Zhao-dong ;

Dai, Qi-shan ;

Ling, Xiao-hui ;

Fu, Xin ;

Lin, Zhuo-yuan ;

Deng, Ye-han ;

Qin, Guo-qiang ;

Cai, Chao ;

Chen, Jia-hong ;

Zhong, Wei-de .

FEBS LETTERS, 2012, 586 (16) :2451-2458

[6]

Carcinoma of the ovary [J].

Heintz, A. P. M. ;

Odicino, F. ;

Maisonneuve, P. ;

Quinn, M. A. ;

Benedet, J. L. ;

Creasman, W. T. ;

Ngan, H. Y. S. ;

Pecorelli, S. ;

Beller, U. .

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 2006, 95 :S161-S192

[7]

The microRNA-23b/-27b Cluster Suppresses the Metastatic Phenotype of Castration-Resistant Prostate Cancer Cells [J].

Ishteiwy, Reema A. ;

Ward, Toby M. ;

Dykxhoorn, Derek M. ;

Burnstein, Kerry L. .

PLOS ONE, 2012, 7 (12)

[8]

Recent Progress in the Diagnosis and Treatment of Ovarian Cancer [J].

Jelovac, Danijela ;

Armstrong, Deborah K. .

CA-A CANCER JOURNAL FOR CLINICIANS, 2011, 61 (03) :183-203

[9]

Prooncogenic Factors miR-23b and miR-27b Are Regulated by Her2/Neu, EGF, and TNF-α in Breast Cancer [J].

Jin, Lianjin ;

Wessely, Oliver ;

Marcusson, Eric G. ;

Ivan, Cristina ;

Calin, George A. ;

Alahari, Suresh K. .

CANCER RESEARCH, 2013, 73 (09) :2884-2896

[10]

Breast-feeding and risk of epithelial ovarian cancer [J].

Jordan, S. J. ;

Cushing-Haugen, K. L. ;

Wicklund, K. G. ;

Doherty, J. A. ;

Rossing, M. A. .

CANCER CAUSES & CONTROL, 2012, 23 (06) :919-927

← 1 2 3 →