A complex phosphodiesterase system controls β-adrenoceptor signalling in cardiomyocytes

被引：20

作者：

Mongillo, M.

Zaccolo, M.

机构：

[1] Venetian Inst Mol Med, Dulbecco Telethon Inst, I-35100 Padua, Italy

[2] Univ London Imperial Coll Sci Technol & Med, Fac Med, Clin Sci Ctr, MRC, London W12 0NN, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2006年 / 34卷

关键词：

adenylate cyclase (AC); beta-adrenoceptor; cAMP; cardiomyocyte; phosphodiesterase (PDE); protein kinase A (PKA);

D O I：

10.1042/BST0340510

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

beta-Adrenergic signalling mediates the positive inotropic effect of catecholamines on cardiomyocytes, mainly through cAMP generation and subsequent activation of PKA (protein kinase A). Given the large diversity of PKA targets within cardiac cells, a precisely regulated and confined activity of such signalling pathways is essential for the specificity of response. PDEs (phosphodiesterases) constitute the only cAMP-degrading mechanism and are expressed in the cardiomyocyte in at least 5 family variants. Each PDE family is characterized by unique functional properties and contributes to a cAMP-degrading system enabling the modulation of PKA activity in a stimulus-dependent fashion.

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收藏

页码：510 / 511

页数：2

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