Tumor protein D52 (TPD52) and cancer-oncogene understudy or understudied oncogene?

被引：69

作者：

Byrne, Jennifer A. ^{[1
,2
]}

Frost, Sarah ^{[1
,2
]}

Chen, Yuyan ^{[1
,2
]}

Bright, Robert K. ^{[3
,4
]}

机构：

[1] Childrens Hosp Westmead, Kids Res Inst, Mol Oncol Lab, Childrens Canc Res Unit, Westmead, NSW 2145, Australia

[2] Univ Sydney, Discipline Paediat & Child Hlth, Childrens Hosp Westmead, Westmead, NSW 2145, Australia

[3] Texas Tech Univ, Hlth Sci Ctr, Dept Immunol & Mol Microbiol, Lubbock, TX 79430 USA

[4] Texas Tech Univ, Hlth Sci Ctr, TTUH SC Canc Ctr, Lubbock, TX 79430 USA

来源：

TUMOR BIOLOGY | 2014年 / 35卷 / 08期

关键词：

TPD52; PrLZ; CRHSP-28; Geneamplification; Tumor antigen; TUMOR PROTEIN D52; DIFFERENTIAL GENE-EXPRESSION; CELL LUNG-CARCINOMA; PROSTATE-CANCER; BREAST-CANCER; COPY NUMBER; ERBB2/NEU-INDUCED TUMORS; ANTIGEN TPD52; IDENTIFICATION; BIOMARKERS;

D O I：

10.1007/s13277-014-2006-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The Tumor protein D52 (TPD52) gene was identified nearly 20 years ago through its overexpression in human cancer, and a substantial body of data now strongly supports TPD52 representing a gene amplification target at chromosome 8q21.13. This review updates progress toward understanding the significance of TPD52 overexpression and targeting, both in tumors known to be characterized by TPD52 overexpression/amplification, and those where TPD52 overexpression/amplification has been recently or variably reported. We highlight recent findings supporting microRNA regulation of TPD52 expression in experimental systems and describe progress toward deciphering TPD52's cellular functions, particularly in cancer cells. Finally, we provide an overview of TPD52's potential as a cancer biomarker and immunotherapeutic target. These combined studies highlight the potential value of genes such as TPD52, which are overexpressed in many cancer types, but have been relatively understudied.

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收藏

页码：7369 / 7382

页数：14

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