Capacity for 5-HT1A-mediated autoregulation predicts amygdala reactivity

被引：124

作者：

Fisher, P. M.

Meltzer, C. C.

Ziolko, S. K.

Price, J. C.

Hariri, A. R. ^{[1
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA

[3] Univ Pittsburgh, Sch Med, Dept Radiol, Pittsburgh, PA 15213 USA

来源：

NATURE NEUROSCIENCE | 2006年 / 9卷 / 11期

关键词：

D O I：

10.1038/nn1780

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the contribution of 5-HT1A autoreceptors ( with [ C-11] WAY100635 positron emission tomography) to amygdala reactivity ( with blood oxygenation level - dependent functional magnetic resonance imaging) in 20 healthy adult volunteers. We found a significant inverse relationship wherein 5-HT1A autoreceptor density predicted a notable 30 - 44% of the variability in amygdala reactivity. Our data suggest a potential molecular mechanism by which a reduced capacity for negative feedback regulation of 5-HT release is associated with increased amygdala reactivity.

引用

页码：1362 / 1363

页数：2

共 12 条

[1]

Arborelius L, 1999, IDrugs, V2, P121

[2] Serotonin and drug-induced therapeutic responses in major depression, obsessive-compulsive and panic disorders [J].