Buffering mitochondrial DNA variation

被引:14
作者
Baughman, Joshua M.
Mootha, Vamsi K.
机构
[1] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA 02114 USA
关键词
D O I
10.1038/ng1106-1232
中图分类号
Q3 [遗传学];
学科分类号
071007 [遗传学]; 090102 [作物遗传育种];
摘要
Reactive oxygen species (ROS) are traditionally viewed as the toxic by-product of cellular respiration. A new study suggests a homeostatic role for ROS in maintaining stable respiratory phenotypes across genetic variants of the mitochondrial genome.
引用
收藏
页码:1232 / 1233
页数:2
相关论文
共 10 条
[1]
SEQUENCE AND ORGANIZATION OF THE HUMAN MITOCHONDRIAL GENOME [J].
ANDERSON, S ;
BANKIER, AT ;
BARRELL, BG ;
DEBRUIJN, MHL ;
COULSON, AR ;
DROUIN, J ;
EPERON, IC ;
NIERLICH, DP ;
ROE, BA ;
SANGER, F ;
SCHREIER, PH ;
SMITH, AJH ;
STADEN, R ;
YOUNG, IG .
NATURE, 1981, 290 (5806) :457-465
[2]
Selection of a mtDNA sequence variant in hepatocytes of heteroplasmic mice is not due to differences in respiratory chain function or efficiency of replication [J].
Battersby, BJ ;
Shoubridge, EA .
HUMAN MOLECULAR GENETICS, 2001, 10 (22) :2469-2479
[3]
Mechanisms of disease: Mitochondrial respiratory-chain diseases [J].
DiMauro, S ;
Schon, EA .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (26) :2656-2668
[4]
Superoxide activates mitochondrial uncoupling proteins [J].
Echtay, KS ;
Roussel, D ;
St-Pierre, J ;
Jekabsons, MB ;
Cadenas, S ;
Stuart, JA ;
Harper, JA ;
Roebuck, SJ ;
Morrison, A ;
Pickering, S ;
Clapham, JC ;
Brand, MD .
NATURE, 2002, 415 (6867) :96-99
[5]
Reactive oxygen species have a causal role in multiple forms of insulin resistance [J].
Houstis, N ;
Rosen, ED ;
Lander, ES .
NATURE, 2006, 440 (7086) :944-948
[6]
HUMAN-CELLS LACKING MTDNA - REPOPULATION WITH EXOGENOUS MITOCHONDRIA BY COMPLEMENTATION [J].
KING, MP ;
ATTARDI, G .
SCIENCE, 1989, 246 (4929) :500-503
[7]
Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants [J].
Moreno-Loshuertos, Raquel ;
Acin-Perez, Rebeca ;
Fernandez-Silva, Patricio ;
Movilla, Nieves ;
Perez-Martos, Acisclo ;
de Cordoba, Santiago Rodriguez ;
Gallardo, M. Esther ;
Enriquez, Jose Antonio .
NATURE GENETICS, 2006, 38 (11) :1261-1268
[8]
Between genotype and phenotype: Protein chaperones and evolvability [J].
Rutherford, SL .
NATURE REVIEWS GENETICS, 2003, 4 (04) :263-274
[9]
REQUIREMENT FOR GENERATION OF H2O2 FOR PLATELET-DERIVED GROWTH-FACTOR SIGNAL-TRANSDUCTION [J].
SUNDARESAN, M ;
YU, ZX ;
FERRANS, VJ ;
IRANI, K ;
FINKEL, T .
SCIENCE, 1995, 270 (5234) :296-299
[10]
Wallace DC, 2003, COLD SPRING HARB SYM, V68, P479