Serotonergic targets in depression

被引:76
作者
Middlemiss, DN [1 ]
Price, GW [1 ]
Watson, JM [1 ]
机构
[1] GlaxoSmithKline, Psychiat Ctr Excellence Drug Discovery, Harlow CM19 5AW, Essex, England
关键词
D O I
10.1016/S1471-4892(01)00116-3
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Serotonin reuptake inhibitors have proved to be a very effective treatment for depression and have strengthened the hypothesis that impaired 5-hydroxytryptamine (5-HT) neurotransmission may contribute to the underlying cause of depressive disorders. Extensive research has been carried out to investigate other 5-HT targets associated with the disease and studies involving combination treatments with selective serotonin reuptake inhibitors and 5-HT1A receptor ligands are currently being carried out in the clinic. Whether other 5-HT receptor subtypes are involved in the aetiology of depression remains to be seen.
引用
收藏
页码:18 / 22
页数:5
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