Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5

被引：174

作者：

Kim, Taewan ^{[1
]}

Cui, Ri ^{[1
,4
]}

Jeon, Young-Jun ^{[1
]}

Lee, Ji-Hoon ^{[5
]}

Lee, Ju Hee ^{[6
]}

Sim, Hosung ^{[7
]}

Park, Jong Kook ^{[8
]}

Fadda, Paolo ^{[1
]}

Tili, Esmerina ^{[1
,2
]}

Nakanishi, Hiroshi ^{[1
]}

Huh, Man-Il ^{[9
]}

Kim, Sung-Hak ^{[3
,10
]}

Cho, Ju Hwan ^{[11
]}

Sung, Bong Hwan ^{[12
]}

Peng, Yong ^{[1
]}

Lee, Tae Jin ^{[1
]}

Luo, Zhenghua ^{[1
]}

Sun, Hui-Lung ^{[1
]}

Wei, Huijun ^{[1
]}

Alder, Hansjuerg ^{[1
]}

Oh, Jeong Su ^{[13
]}

Shim, Kang Sup ^{[1
]}

Ko, Sang-Bong ^{[14
]}

Croce, Carlo M. ^{[1
]}

机构：

[1] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

[2] Ohio State Univ, Wexner Med Ctr, Dept Anesthesiol, Columbus, OH 43210 USA

[3] Ohio State Univ, Dept Neurol Surg, Columbus, OH 43210 USA

[4] YanBian Univ, Dept Pathol, Affiliated Hosp, Yanji 133002, Peoples R China

[5] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75235 USA

[6] Univ Calif Santa Cruz, Dept Appl Math & Stat, Santa Cruz, CA 95064 USA

[7] Univ Michigan, Sch Med, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA

[8] Northwestern Univ, Dept Dermatol, Chicago, IL 60208 USA

[9] Kyungpook Natl Univ, Sch Med, Dept Ophthalmol, Taegu 700842, South Korea

[10] Korea Univ, Sch Life Sci & Biotechnol, Seoul 136702, South Korea

[11] Ohio State Univ, Med Ctr, Arthur G James Comprehens Canc Ctr, Dept Radiat Oncol, Columbus, OH 43210 USA

[12] Vanderbilt Univ, Med Ctr, Dept Canc Biol, Nashville, TN 37232 USA

[13] Sungkyunkwan Univ, Dept Genet Engn, Suwon 110745, South Korea

[14] Catholic Univ Daegu, Sch Med, Daegu Catholic Univ, Dept Orthoped Surg,Med Ctr, Taegu 705718, South Korea

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2014年 / 111卷 / 11期

关键词：

GENOME-WIDE ASSOCIATION; COLORECTAL-CANCER; PROSTATE-CANCER; SNP RS6983267; CHROMOSOME; 8Q24; COLON-CANCER; RISK LOCUS; EXPRESSION; VARIANT; TISSUE;

D O I：

10.1073/pnas.1400350111

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

The mechanism by which the 8q24 MYC enhancer region, including cancer-associated variant rs6983267, increases cancer risk is unknown due to the lack of protein-coding genes at 8q24.21. Here we report the identification of long noncoding RNAs named cancer-associated region long noncoding RNAs (CARLos) in the 8q24 region. The expression of one of the long noncoding RNAs, CARLo-5, is significantly correlated with the rs6983267 allele associated with increased cancer susceptibility. We also found the MYC enhancer region physically interacts with the active regulatory region of the CARLo-5 promoter, suggesting long-range interaction of MYC enhancer with the CARLo-5 promoter regulates CARLo-5 expression. Finally, we demonstrate that CARLo-5 has a function in cell-cycle regulation and tumor development. Overall, our data provide a key of the mystery of the 8q24 gene desert.

引用

页码：4173 / 4178

页数：6

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