Total homocysteine and cardiovascular disease

被引：205

作者：

Nygård, O

Vollset, SE

Refsum, H

Brattström, L

Ueland, PM

机构：

[1] Univ Bergen, Dept Publ Hlth & Primary Care, Div Med Stat, Bergen, Norway

[2] Univ Bergen, Dept Pharmacol, Bergen, Norway

[3] Cty Hosp, Dept Med, Kalmar, Sweden

来源：

JOURNAL OF INTERNAL MEDICINE | 1999年 / 246卷 / 05期

关键词：

homocysteine; atherosclerosis; cardiovascular disease; pathogenesis;

D O I：

10.1046/j.1365-2796.1999.00512.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent data have shown that an elevated plasma level of the amino acid homocysteine (Hcy) is a common, independent, easily modifiable and possibly causal risk factor for cardiovascular disease (CVD) which may be of equal importance to hypercholesterolemia, hypertension and smoking. This paper reviews the biochemical, clinical, epidemiological and experimental data underlying this conclusion and is critically questioning whether elevated tHcy is a causal factor.

引用

页码：425 / 454

页数：30

共 389 条

[41] Hyperhomocysteinemia in end-stage renal disease: Prevalence, etiology, and potential relationship to arteriosclerotic outcomes [J].