Cp2Fe(PR2)2PdCl2 (R = i-Pr, t-Bu) complexes as air-stable catalysts for challenging suzuki coupling reactions

被引：132

作者：

Colacot, TJ

Shea, HA

机构：

[1] Johnson Matthey, Catalysis & Chiral Technol, W Deptford, NJ 08066 USA

[2] Pharm Eco, Catalyt Serv, Devens, MA 01434 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 21期

关键词：

D O I：

10.1021/ol048598t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use Of CP2Fe(PR2)(2)PdCl2 (R = i-Pr and t-Bu) in Suzuki coupling reactions were illustrated using a high throughput screening approach. The di-tbpfPdCl(2) catalyst was shown to be the more active catalyst for unactivated and sterically challenging aryl chlorides. Comparison studies using the commercial catalysts dppfPdCl(2), (Ph3P)(2)PdCl2, (Cy3P)(2)PdCl2, DPEPhosPdCl(2), dppbPdCl(2), dppePdCl(2), Pd(t-BU3P)(2), and [Pd-(mu-Br)(t-Bu3P)](2) were also done for selected cases to demonstrate the superior activities of di-tbpfPdCl(2) and di-isoppfPdCl(2).

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页码：3731 / 3734

页数：4

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