Genome-wide association study identifies five susceptibility loci for glioma

被引：625

作者：

Shete, Sanjay ^{[2
]}

Hosking, Fay J. ^{[1
]}

Robertson, Lindsay B. ^{[1
]}

Dobbins, Sara E. ^{[1
]}

Sanson, Marc ^{[3
,4
,6
]}

Malmer, Beatrice ^{[5
]}

Simon, Matthias

Marie, Yannick ^{[3
,4
]}

Boisselier, Blandine ^{[3
,4
]}

Delattre, Jean-Yves ^{[3
,4
]}

Hoang-Xuan, Khe ^{[3
,4
]}

El Hallani, Soufiane ^{[3
,4
]}

Idbaih, Ahmed ^{[3
,4
]}

Zelenika, Diana ^{[7
]}

Andersson, Ulrika ^{[5
]}

Henriksson, Roger ^{[5
]}

Bergenheim, A. Tommy ^{[8
]}

Feychting, Maria ^{[9
]}

Lonn, Stefan ^{[10
]}

Ahlbom, Anders ^{[9
]}

Schramm, Johannes ^{[6
]}

Linnebank, Michael ^{[11
]}

Hemminki, Kari ^{[12
]}

Kumar, Rajiv ^{[12
]}

Hepworth, Sarah J. ^{[13
]}

Price, Amy ^{[1
]}

Armstrong, Georgina ^{[2
]}

Liu, Yanhong ^{[2
]}

Gu, Xiangjun ^{[2
]}

Yu, Robert ^{[2
]}

Lau, Ching ^{[14
]}

Schoemaker, Minouk ^{[15
]}

Muir, Kenneth ^{[16
]}

Swerdlow, Anthony ^{[15
]}

Lathrop, Mark ^{[7
,17
]}

Bondy, Melissa ^{[2
]}

Houlston, Richard S. ^{[1
]}

机构：

[1] Inst Canc Res, Sect Canc Genet, Sutton, Surrey, England

[2] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA

[3] UPMC, GH Pitie Salpetriere, AP HP, Serv Neurol Mazarin, Paris, France

[4] UPMC, GH Pitie Salpetriere, AP HP, INSERM,UMR 975, Paris, France

[5] Umea Univ, Dept Radiat Sci, Umea, Sweden

[6] Neurochirurg Univ Klin Bonn, Bonn, Germany

[7] IG CEA, Ctr Natl Genotypage, Evry, France

[8] Umea Univ, Dept Clin Neurosci, Umea, Sweden

[9] Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden

[10] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[11] Univ Zurich Hosp, Dept Neurol, CH-8091 Zurich, Switzerland

[12] German Canc Res Ctr, Div Mol Genet Epidemiol, D-6900 Heidelberg, Germany

[13] Univ Leeds, Fac Med & Hlth, Ctr Biostat & Epidemiol, Leeds, W Yorkshire, England

[14] Baylor Coll Med, Texas Childrens Canc Ctr, Houston, TX 77030 USA

[15] Inst Canc Res, Epidemiol Sect, Sutton, Surrey, England

[16] Univ Nottingham, Sch Med, Div Epidemiol & Publ Hlth, Queens Med Ctr, Nottingham, England

[17] Fdn Jean Dausett CEPH, Paris, France

来源：

NATURE GENETICS | 2009年 / 41卷 / 08期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

NERVOUS-SYSTEM TUMORS; BIRTH-WEIGHT; GENE-EXPRESSION; BREAST-CANCER; RETINOIC ACID; RISK; POPULATION; GLIOBLASTOMA; DELETION; 8Q24;

D O I：

10.1038/ng.407

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

To identify risk variants for glioma, we conducted a meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs in a total of 1,878 cases and 3,670 controls, with validation in three additional independent series totaling 2,545 cases and 2,953 controls. We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). These data show that common low-penetrance susceptibility alleles contribute to the risk of developing glioma and provide insight into disease causation of this primary brain tumor.

引用

页码：899 / U54

页数：8

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