Three-dimensional magnetic resonance spectroscopic imaging of brain and prostate cancer

被引:133
作者
Kurhanewicz, J [1 ]
Vigneron, DB [1 ]
Nelson, SJ [1 ]
机构
[1] Univ Calif San Francisco, Magnet Resonance Sci Ctr, Dept Radiol, San Francisco, CA 94143 USA
来源
NEOPLASIA | 2000年 / 2卷 / 1-2期
关键词
magnetic resonance spectroscopic imaging (MRSI); prostate and brain cancer; metabolism; magnetic resonance imaging (MRI); morphology;
D O I
10.1038/sj.neo.7900081
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Clinical applications of magnetic resonance spectroscopic imaging (MRSI) for the study of brain and prostate cancer have expanded significantly over the past 10 years. Proton MRSI studies of the brain and prostate have demonstrated the feasibility of noninvasively assessing human cancers based on metabolite levels before and after therapy in a clinically reasonable amount of time, MRSI provides a unique biochemical "window" to study cellular metabolism noninvasively, MRSI studies have demonstrated dramatic spectral differences between normal brain tissue (low choline and high N-acetyl aspartate, NAA) and prostate (low choline and high citrate) compared to brain (low NAA, high choline) and prostate (low citrate, high choline) tumors. The presence of edema and necrosis in both the prostate and brain was reflected by a reduction of the intensity of all resonances due to reduced cell density. MRSI was able to discriminate necrosis (absence of all metabolites, except lipids and lactate) from viable normal tissue and cancer following therapy. The results of current MRSI studies also provide evidence that the magnitude of metabolic changes in regions of cancer before therapy as well as the magnitude and time course of metabolic changes after therapy can improve our understanding of cancer aggressiveness and mechanisms of therapeutic response. Clinically, combined MRI/MRSI has already demonstrated the potential for improved diagnosis, staging and treatment planning of brain and prostate cancer. Additionally, studies are under way to determine the accuracy of anatomic and metabolic parameters in providing an objective quantitative basis for assessing disease progression and response to therapy.
引用
收藏
页码:166 / 189
页数:24
相关论文
共 206 条
  • [21] PRACTICAL APPLICATIONS OF CHEMICAL-SHIFT IMAGING
    BROWN, TR
    [J]. NMR IN BIOMEDICINE, 1992, 5 (05) : 238 - 243
  • [22] NMR CHEMICAL-SHIFT IMAGING IN 3 DIMENSIONS
    BROWN, TR
    KINCAID, BM
    UGURBIL, K
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (11): : 3523 - 3526
  • [23] MR IMAGING - CLINICAL USE OF THE INVERSION RECOVERY SEQUENCE
    BYDDER, GM
    YOUNG, IR
    [J]. JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1985, 9 (04) : 659 - 675
  • [24] HYDROLYSIS OF PHOSPHATIDYLCHOLINE COUPLES RAS TO ACTIVATION OF RAF PROTEIN-KINASE DURING MITOGENIC SIGNAL-TRANSDUCTION
    CAI, H
    ERHARDT, P
    TROPPMAIR, J
    DIAZMECO, MT
    SITHANANDAM, G
    RAPP, UR
    MOSCAT, J
    COOPER, GM
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (12) : 7645 - 7651
  • [25] CARNERO A, 1994, ONCOGENE, V9, P1387
  • [26] MODULATIONS OF GLYCEROPHOSPHORYLCHOLINE AND PHOSPHORYLCHOLINE IN FRIEND-ERYTHROLEUKEMIA CELLS UPON INVITRO-INDUCED ERYTHROID-DIFFERENTIATION - A P-31 NMR-STUDY
    CARPINELLI, G
    PODO, F
    DIVITO, M
    PROIETTI, E
    GESSANI, S
    BELARDELLI, F
    [J]. FEBS LETTERS, 1984, 176 (01) : 88 - 92
  • [27] USE OF ENDORECTAL SURFACE COIL MAGNETIC-RESONANCE-IMAGING FOR LOCAL STAGING OF PROSTATE-CANCER
    CHELSKY, MJ
    SCHNALL, MD
    SEIDMON, EJ
    POLLACK, HM
    [J]. JOURNAL OF UROLOGY, 1993, 150 (02) : 391 - 395
  • [28] CHEN CN, 1989, MED SCI SERIES
  • [29] Hormonal ablation of prostatic cancer: Effects on prostate morphology, tumor detection, and staging by endorectal coil MR imaging
    Chen, M
    Hricak, H
    Kalbhen, CL
    Kurhanewicz, J
    Vigneron, DB
    Weiss, JM
    Carroll, PR
    [J]. AMERICAN JOURNAL OF ROENTGENOLOGY, 1996, 166 (05) : 1157 - 1163
  • [30] Cheng LL, 1998, CANCER RES, V58, P1825