Inhibition of phosphatase activity by positively-charged cyclodextrins

被引：11

作者：

Ghosh, M ^{[1
]}

Sanders, TC ^{[1
]}

Zhang, R ^{[1
]}

Seto, CT ^{[1
]}

机构：

[1] Brown Univ, Dept Chem, Providence, RI 02912 USA

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 12期

关键词：

D O I：

10.1021/ol990301h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Aminocyclodextrins are known to hind phosphate esters such as phosphotyrosine and p-nitrophenyl phosphate, This paper describes the inhibition of phosphate ester hydrolysis, as catalyzed by lambda-protein phosphatase and acid phosphatase, that is caused by such binding interactions. ROESY studies provide structural information about the cyclodextrin-aryl phosphate complexes. In addition, these experiments are used to generate approximations of the rates of dissociation of the noncovalent complexes.

引用

页码：1945 / 1948

页数：4

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