'O-acyl isopeptide method':: racemization-free segment condensation in solid phase peptide synthesis

被引：41

作者：

Yoshiya, Taku

Sohma, Youhei

Kimura, Tooru

Hayashia, Yoshio

Kiso, Yoshiaki ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Dept Med Chem, Ctr Frontier Res Med Sci, 21st Century COE Program,Yamashina Ku, Kyoto 6078412, Japan

[2] Kyoto Pharmaceut Univ, Dept Chem Phys, 21st Century COE Program, Yamashina Ku, Kyoto 6078412, Japan

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 45期

基金：

日本学术振兴会;

关键词：

O-acyl isodipeptide unit; O-acyl isopeptide method; O-N intramolecular acyl migration; racemization-free; segment condensation;

D O I：

10.1016/j.tetlet.2006.09.001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We disclosed a novel 'racemization-free segment condensation' based on the 'O-acyl isopeptide method' in which an N-segment including C-terminal O-acyl isopeptide structure with urethane-protected Ser/Thr residue was employed for the segment condensation, suggesting that the use of this method contributes to the effective convergent synthesis of long peptides/proteins. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：7905 / 7909

页数：5

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