PEDF: a potential molecular therapeutic target with multiple anti-cancer activities

被引：116

作者：

Ek, Eugene T. H. ^{[1
]}

Dass, Crispin R. ^{[1
]}

Choong, Peter F. M. ^{[1
]}

机构：

[1] Univ Melbourne, St Vincents Hosp, Dept Orthopaed, Melbourne, Vic, Australia

来源：

TRENDS IN MOLECULAR MEDICINE | 2006年 / 12卷 / 10期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.molmed.2006.08.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pigment epithelium-derived factor (PEDF) is an endogenously produced protein that is widely expressed throughout the human body, and exhibits multiple and varied biological activities. Already established as a potent anti-angiogenic molecule, PEDF has recently shown promise as a potential anti-tumour agent, causing both direct and indirect tumour suppression. Here, we explore the unique anti-tumour properties of PEDF and discuss its role as an effective anti-angiogenic, anti-proliferative and pro-differentiation factor. We also discuss the prospects for PEDF therapy and the need for a closer evaluation of issues such as delivery, stability and potential toxicity.

引用

页码：497 / 502

页数：6

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