Label-free bioaffinity detection using terahertz technology

被引：134

作者：

Mickan, SP ^{[1
]}

Menikh, A

Liu, HB

Mannella, CA

MacColl, R

Abbott, D

Munch, J

Zhang, XC

机构：

[1] Rensselaer Polytech Inst, Dept Phys Appl Phys & Astron, Ctr Terahertz Res, Troy, NY 12180 USA

[2] New York State Dept Hlth, Wadsworth Ctr Labs & Res, Albany, NY 12201 USA

[3] Univ Adelaide, Ctr Biomed Engn, Adelaide, SA 5005, Australia

[4] Univ Adelaide, Dept Elect & Elect Engn, Adelaide, SA 5005, Australia

[5] Univ Adelaide, Dept Phys & Math Phys, Adelaide, SA 5005, Australia

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 2002年 / 47卷 / 21期

关键词：

D O I：

10.1088/0031-9155/47/21/317

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We report the first use of differential terahertz time-domain spectroscopy for bioaffinity sensing. Binding is observed by measuring the transmission of a thin layer of biotin bound to the sensor protein avidin. We demonstrate the THz wave transmission of a sub-micron-thick film and sensitivity to 0.1 mug cm(-2) of biotin. These results point the way for a host of biosensor applications using T-rays, or pulsed far-infrared (FIR) radiation.

引用

页码：3789 / 3795

页数：7

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