The role of Th17 and Treg responses in the pathogenesis of RSV infection

被引:85
作者
Mangodt, Thomas C. [1 ]
Van Herck, Mikhail A. [1 ]
Nullens, Sara [2 ]
Ramet, Jose [1 ,2 ,3 ]
De Dooy, Jozef J. [2 ,4 ]
Jorens, Philippe G. [1 ,2 ,4 ]
De Winter, Benedicte Y. [2 ]
机构
[1] Univ Antwerp, Fac Med & Hlth Sci, B-2020 Antwerp, Belgium
[2] Univ Antwerp, Lab Expt Med & Pediat, B-2020 Antwerp, Belgium
[3] Univ Antwerp Hosp, Dept Pediat, Edegem, Belgium
[4] Univ Antwerp Hosp, Dept Crit Care Med, Edegem, Belgium
关键词
RESPIRATORY SYNCYTIAL VIRUS; REGULATORY T-CELLS; TRANSLATIONAL MINIREVIEW SERIES; HELPER; 17; CELLS; TGF-BETA; IMMUNE-RESPONSE; PULMONARY IMMUNOPATHOLOGY; DIFFERENTIATION; TH2; CYTOKINES;
D O I
10.1038/pr.2015.143
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The respiratory syncytial virus (RSV) represents the leading cause of viral bronchiolitis and pneumonia in children worldwide and is associated with high morbidity, hospitalization rate, and significant mortality rates. The immune response elicited by RSV is one of the main factors contributing to the pathogenesis of the disease. Two subsets of the cellular immune response, the T helper 17 cell (Th17) and the regulatory T-cell (Treg), and more particularly the balance between these two subsets, might play a significant role in the pathogenesis of the RSV infection. The developmental pathways of Th17 and Treg cells are closely and reciprocally interconnected and plasticity has been demonstrated from Treg toward Th17. During an RSV infection, the functions of both subsets are opposed to one another regarding viral clearance and clinical severity. Th17 and Treg cells offer a promising new view on the pathogenesis of an RSV infection and deserve further exploration.
引用
收藏
页码:483 / 491
页数:9
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