Enantio- and diastereoselective allylmetalations: An easy and efficient access to the AB spiroketal of spongistatin

被引：25

作者：

Allais, Florent ^{[1
]}

Cossy, Janine ^{[1
]}

机构：

[1] CNRS, Chim Organ Lab, ESPCI, F-75231 Paris 05, France

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 17期

关键词：

D O I：

10.1021/ol060812l

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A unique combination of highly enantio- and diastereoselective allylmetalations and a one-pot "desacetalization/spiroketalization" have been employed to synthesize the AB spiroketal fragment (C1 - C13) of spongistatin in 15 steps and in excellent diastereoselectivity.

引用

页码：3655 / 3657

页数：3

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