Synthesis of some cyclic indolic peptoids as potential antibacterials

被引：19

作者：

Au, Vicki S.

Bremner, John B. ^{[1
]}

Coates, Jonathan

Keller, Paul A.

Pyne, Stephen G.

机构：

[1] Univ Wollongong, Dept Chem, Wollongong, NSW 2522, Australia

[2] Avexa Ltd, Richmond, Vic 3121, Australia

来源：

TETRAHEDRON | 2006年 / 62卷 / 40期

关键词：

cyclic peptoid; antibacterial; ring-closing metathesis; indole;

D O I：

10.1016/j.tet.2006.07.059

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of cyclic peptoids containing an indole hydrophobic scaffold has been realised through the ring-closing metathesis of diallylated precursors. The precursors and their cyclic counterparts possessed poor antibacterial activity in contrast to previously reported cyclic peptoids containing hydrophobic scaffolds. (c) 2006 Elsevier Ltd. All rights reserved.

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收藏

页码：9373 / 9382

页数：10

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