A novel method for preparation of trifluoromethyl substituted 2,3-dihydro-1,4-diazepine and benzimidazole

被引：11

作者：

Chu, QL ^{[1
]}

Wang, YL ^{[1
]}

Zhu, SZ ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2000年 / 30卷 / 04期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1080/00397910008087370

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ethylenediamine reacted readily with 4-ethoxy-1,1,1-trifluoro-3-butene-2-one to form 5-trifluoromethyl-2,3-dihydro-1,4-diazepine in good yield. Under the same reaction conditions o-phenylene diamine gave 2-trifluoromethyl benzimidazole and benzimidazole.

引用

页码：677 / 687

页数：11

共 12 条

[1]

Allain L, 1998, SYNTHESIS-STUTTGART, P847

[2] SYNTHESIS OF BETA-CHLORO(TRIFLUOROMETHYL)ACROLEINS AND A SPECIFIC REACTION TOWARDS BETA-AMINOTHIOLS [J].

ALVERNHE, G ;

LANGLOIS, B ;

LAURENT, A ;

LEDREAN, I ;

SELMI, A ;

WEISSENFELS, M .

TETRAHEDRON LETTERS, 1991, 32 (05) :643-646

[3] REACTION OF SELENOUS ACID WITH THIOSALICYLIC ACID, 2-MERCAPTOBENZOTHIAZOLE AND 2-AMINOTHIOPHENOL [J].

BUDESINSKY, BW ;

SVEC, J .

JOURNAL OF INORGANIC & NUCLEAR CHEMISTRY, 1971, 33 (11) :3795-+

[4]

Filler R., 1993, ORGANOFLUORINE COMPO

[5] THE INTERACTION OF 4-ETHOXY-1,1,1-TRIFLUORO-3-BUTEN-2-ONE WITH C-NUCLEOPHILES - ORGANO-MAGNESIUM AND ORGANO-ZINC COMPOUNDS [J].

GORBUNOVA, MG ;

GERUS, II ;

KUKHAR, VP .

JOURNAL OF FLUORINE CHEMISTRY, 1993, 65 (1-2) :25-28

[6] Study of the nucleophilic reaction of 2-mercaptoethanol with 1-fluoroalkyl-2-iodo-alkenes [J].

Guan, HP ;

Luo, BH ;

Hu, CM .

JOURNAL OF FLUORINE CHEMISTRY, 1997, 85 (02) :141-145

[7] 2-TRIHALOGENOMETHYLBENZAZOLES .I. FORMATION [J].

HOLAN, G ;

SAMUEL, EL ;

ENNIS, BC ;

HINDE, RW .

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1967, (01) :20-&

[8] SYNTHESIS OF 3-HYDROXY-5-PER(POLY)FLUOROALKYL PYRAZOLES [J].

HU, QS ;

GUAN, HP ;

HU, CM .

JOURNAL OF FLUORINE CHEMISTRY, 1995, 75 (01) :51-54

[9] SYNTHESIS OF SOME FLUORINATED NITROGEN-HETEROCYCLES FROM (DIETHYLAMINOMETHYLENE)HEXAFLUOROACETYLACETONE (DAMFA) [J].

SOUFYANE, M ;

MIRAND, C ;

LEVY, J .

TETRAHEDRON LETTERS, 1993, 34 (48) :7737-7740

[10] Synthesis of 5-per(poly)fluoroalkyl-2,3-dihydro-1,4-diazepines [J].

Wang, QF ;

Hu, B ;

Luo, BH ;

Hu, CM .

TETRAHEDRON LETTERS, 1998, 39 (16) :2377-2380

← 1 2 →