Influence of ageing on ciliary beat frequency and on ciliary response to leukotriene D4 in guinea-pig tracheal epithelium

被引：4

作者：

Joki, S

Saano, V

机构：

[1] Dept. of Pharmacology and Toxicology, University of Kuopio, Kuopio

[2] Dept. of Pharmacology and Toxicology, University of Kuopio, FIN-70211 Kuopio

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1997年 / 24卷 / 02期

关键词：

age; ciliary beat frequency; guinea-pig; leukotriene D4;

D O I：

10.1111/j.1440-1681.1997.tb01802.x

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

1. In the present study on guinea-pig tracheal epithelium, the influence of age on ciliary beat frequency (CBF) was investigated. 2. An age-dependent decrease in CBF was seen: as the age of the guinea-pig increased from 0.9 to 16.3 months, CBF decreased from 20.2 to 6.9 Hz. 3. The effect of leukotriene D4 (LTD4) on CBF was also examined using tracheal explants from guinea-pigs of varying ages. The lower CBF of the older animal was increased by LTD4 to a larger extent than was the higher CBF seen in explants taken from younger animals. 4. Ciliary activity and possibly also the sensitivity of the cilia to drugs, seems to be dependent upon the age of the animal, which has to be taken into consideration when comparing the results of different studies on the effects of xenobiotics on mucociliary function.

引用

页码：166 / 169

页数：4

共 34 条

[1]

EFFECT OF LEUKOTRIENE D4 ON NASAL MUCOSAL BLOOD-FLOW, NASAL AIRWAY-RESISTANCE AND NASAL SECRETION IN HUMANS [J].