Induction of CD8+ T cells using heterologous prime-boost immunisation strategies

被引：159

作者：

Schneider, J

Gilbert, SC

Hannan, CM

Dégano, P

Prieur, E

Sheu, EG

Plebanski, M

Hill, AVS

机构：

[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Med, Mol Immunol Grp,Inst Mol Med, Oxford OX3 9DU, England

[2] Austin Res Inst, Heidelberg, Vic, Australia

来源：

IMMUNOLOGICAL REVIEWS | 1999年 / 170卷

关键词：

D O I：

10.1111/j.1600-065X.1999.tb01326.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

One of the current challenges in vaccine design is the development of antigen delivery systems or vaccination strategies that induce high protective levels of CD8(+) T cells. These cells are crucial for protection against certain rumours and intracellular pathogens such as the liver-stage parasite of malaria. A liver-stage malaria vaccine should therefore include CD8(+) T-cell-inducing components. This review provides an overview of prime-boost immunisation strategies that result in protective CD8(+) T-cell responses against malaria with an emphasis on work from our laboratory. Possible mechanisms explaining why heterologous prime-boost strategies, in particular boosting with replication-impaired recombinant poxviruses, are so effective are discussed.

引用

页码：29 / 38

页数：10

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