Human papillomaviruses in non-melanoma skin cancer

被引：42

作者：

de Villiers, EM ^{[1
]}

Ruhland, A ^{[1
]}

Sekaric, P ^{[1
]}

机构：

[1] Deutsch Krebsforschungszentrum, Res Programme Appl Tumour Virol, Div Tumour Virus Characterizat, D-69120 Heidelberg, Germany

来源：

SEMINARS IN CANCER BIOLOGY | 1999年 / 9卷 / 06期

关键词：

skin cancer; HPV; UV; cytokines;

D O I：

10.1006/scbi.1999.0145

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent data suggest that additional factors, other than UV radiation, are involved in the etiology of non-melanoma skin cancer. These include alterations in the tumor suppressor genes, p53, p16(INK4a)/CDKN2A, p21(WAF1)/(CIP1) and the PTCH gene, as well as cytokines. Papillomavirus infections have been implicated in the etiology of non-melanoma skin cancer. The interaction of tumor suppressor genes and cytokines with the oncoproteins of high-risk mucosal HPV types have been studied in detail, but very little is known about the cutaneous HPV types. We have studied the effect of UV radiation on the URRs of HPV 1, 2, 3, 5, 7, 20, 23, 27, 38, 41, and 77. Neither the CAT-expression and promoter activity of these HPV types, nor presence or absence of wild-type or mutated p53 in the cell lines used, could be related to the DNA sequence homology between the different HPV types or their biological behavior.

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收藏

页码：413 / 422

页数：10

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