Effective and recyclable dendritic catalysts for the direct asymmetric Michael addition of aldehydes to nitrostyrenes

被引：84

作者：

Li, Yawen

Liu, Xin-Yuan

Zhao, Gang ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Anhua 230026, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Lab Modern Synthet Organ Chem, Shanghai 200032, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 2006年 / 17卷 / 13期

基金：

中国国家自然科学基金;

关键词：

PHOSPHORUS-CONTAINING DENDRIMERS; BETA-NITROSTYRENES; NITRO-OLEFINS; 2,3-DISUBSTITUTED 4-NITROKETONES; ENANTIOSELECTIVE ALKYLATIONS; RECOVERABLE CATALYSTS; OMEGA-NITROSTYRENES; ORGANIC-SYNTHESIS; METAL-COMPLEXES; ALDOL REACTIONS;

D O I：

10.1016/j.tetasy.2006.07.004

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Direct catalytic enantio- and diastereoselective Michael addition reaction of aldehydes to nitrostyrenes is described using a series of recyclable chiral 2-trimethylsilanyloxy-methyl-pyrrolidine-based dendritic catalysts. Good yields (up to 82%), and high diastereoselectivities (up to syn/anti = 95/5) and enantioselectivities (up to 99% ee) have been obtained. (c) 2006 Elsevier Ltd. All rights reserved.

引用

收藏

页码：2034 / 2039

页数：6

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