BDNF-TrkB Receptor Regulation of Distributed Adult Neural Plasticity, Memory Formation and Psychiatric Disorders

被引：141

作者：

Andero, Rauel ^{[1
,2
]}

Choi, Dennis C. ^{[1
,2
]}

Ressler, Kerry J. ^{[1
,2
,3
]}

机构：

[1] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA

[2] Yerkes Natl Primate Res Ctr, Atlanta, GA USA

[3] Howard Hughes Med Inst, Chevy Chase, MD USA

来源：

MOLECULAR BASIS OF MEMORY | 2014年 / 122卷

关键词：

POSTTRAUMATIC-STRESS-DISORDER; MEDIAL PREFRONTAL CORTEX; LONG-TERM POTENTIATION; FACTOR VAL66MET POLYMORPHISM; ACTIVITY-DEPENDENT SECRETION; SINGLE PROLONGED STRESS; NEUROTROPHIC-FACTOR; SYNAPTIC PLASTICITY; FEAR EXTINCTION; PANIC DISORDER;

D O I：

10.1016/B978-0-12-420170-5.00006-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Brain-derived neurotrophic factor (BDNF) and its single transmembrane receptor, tropomysin-related kinase B (TrkB), are essential for adult synaptic plasticity and the formation of memories. However, there are regional and task-dependent differences underlying differential mechanisms of BDNF TrkB function in the formation of these memories. Additionally, the BDNF pathway has been implicated in several psychiatric disorders including posttraumatic stress disorder, phobia, and panic disorder. Gaining a better understanding of this pathway and the neurobiology of memory through fundamental research may be helpful to identify effective prevention and treatment approaches both for diseases of memory deficit as well as in cases of enhanced aversive memory, such as in anxiety disorders.

引用

页码：169 / 192

页数：24

共 139 条

[41]

BDNF, Relative Preference, and Reward Circuitry Responses to Emotional Communication [J].

Gasic, G. P. ;

Smoller, J. W. ;

Perlis, R. H. ;

Sun, M. ;

Lee, S. ;

Kim, B. W. ;

Lee, M. J. ;

Holt, D. J. ;

Blood, A. J. ;

Makris, N. ;

Kennedy, D. K. ;

Hoge, R. D. ;

Calhoun, J. ;

Fava, M. ;

Gusella, J. F. ;

Breiter, H. C. .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2009, 150B (06) :762-781

[42]

Prelimbic cortex bdnf knock-down reduces instrumental responding in extinction [J].

Gourley, Shannon L. ;

Howell, Jessica L. ;

Rios, Maribel ;

DiLeone, Ralph J. ;

Taylor, Jane R. .

LEARNING & MEMORY, 2009, 16 (12) :756-760

[43]

A History of Corticosterone Exposure Regulates Fear Extinction and Cortical NR2B, GluR2/3, and BDNF [J].

Gourley, Shannon L. ;

Kedves, Alexia T. ;

Olausson, Peter ;

Taylor, Jane R. .

NEUROPSYCHOPHARMACOLOGY, 2009, 34 (03) :707-716

[44]

DYNAMIC PLASTICITY: THE ROLE OF GLUCOCORTICOIDS, BRAIN-DERIVED NEUROTROPHIC FACTOR AND OTHER TROPHIC FACTORS [J].

Gray, J. D. ;

Milner, T. A. ;

McEwen, B. S. .

NEUROSCIENCE, 2013, 239 :214-227

[45]

Paradoxical reversal learning enhancement by stress or prefrontal cortical damage: rescue with BDNF [J].

Graybeal, Carolyn ;

Feyder, Michael ;

Schulman, Emily ;

Saksida, Lisa M. ;

Bussey, Timothy J. ;

Brigman, Jonathan L. ;

Holmes, Andrew .

NATURE NEUROSCIENCE, 2011, 14 (12) :1507-1509

[46]

A Behavioral Analysis of the Impact of Voluntary Physical Activity on Hippocampus-Dependent Contextual Conditioning [J].

Greenwood, Benjamin N. ;

Strong, Paul V. ;

Foley, Teresa E. ;

Fleshner, Monika .

HIPPOCAMPUS, 2009, 19 (10) :988-1001

[47]

Histone Methylation Regulates Memory Formation [J].

Gupta, Swati ;

Kim, Se Y. ;

Artis, Sonja ;

Molfese, David L. ;

Schumacher, Armin ;

Sweatt, J. David ;

Paylor, Richard E. ;

Lubin, Farah D. .

JOURNAL OF NEUROSCIENCE, 2010, 30 (10) :3589-3599

[48]

Rapid and selective induction of BDNF expression in the hippocampus during contextual learning [J].

Hall, J ;

Thomas, KL ;

Everitt, BJ .

NATURE NEUROSCIENCE, 2000, 3 (06) :533-535

[49]

Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance [J].

Hariri, AR ;

Goldberg, TE ;

Mattay, VS ;

Kolachana, BS ;

Callicott, JH ;

Egan, MF ;

Weinberger, DR .

JOURNAL OF NEUROSCIENCE, 2003, 23 (17) :6690-6694

[50]

Serum brain-derived neurotrophic factor in patients with trauma psychopathology [J].

Hauck, Simone ;

Kapczinski, Flavio ;

Roesler, Rafael ;

Silveira, Erico de Moura, Jr. ;

Magalhaes, Pedro V. ;

Pinto Kruel, Leticia Rosito ;

Schestatsky, Sidnei Samuel ;

Freitas Ceitlin, Lucia Helena .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2010, 34 (03) :459-462

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