Promoter cleavage:: A topoIIβ and PARP-1 collaboration

被引：20

作者：

Lis, John T. ^{[1
]}

Kraus, W. Lee ^{[1
]}

机构：

[1] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA

来源：

CELL | 2006年 / 125卷 / 07期

关键词：

D O I：

10.1016/j.cell.2006.06.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hormones trigger dramatic changes in the structure and transcriptional activity of specific promoters that lead to exchange of repression complexes for activation complexes. Ju et al. (2006) now show that estrogen-dependent restructuring and transcription of the pS2 promoter require the generation of a DNA double-strand break by a novel protein complex containing two enzymes, topoisomerase II beta and poly(ADP-ribose) polymerase.

引用

页码：1225 / 1227

页数：3

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