Role of astrocytic transport processes in glutamatergic and GABAergic neurotransmission

被引：113

作者：

Schousboe, A ^{[1
]}

Sarup, A ^{[1
]}

Bak, LK ^{[1
]}

Waagepetersen, HS ^{[1
]}

Larsson, OM ^{[1
]}

机构：

[1] Danish Univ Pharmaceut Sci, Neurosci Res Ctr, Dept Pharmacol, DK-2100 Copenhagen, Denmark

来源：

NEUROCHEMISTRY INTERNATIONAL | 2004年 / 45卷 / 04期

关键词：

transport inhibitors; synapses; energy failure; anticonvulsants; excitotoxicity;

D O I：

10.1016/j.neuint.2003.11.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The fine tuning of both glutamatergic and GABAergic neurotransmission is to a large extent dependent upon optimal function of astrocytic transport processes. Thus, glutamate transport in astrocytes is mandatory to maintain extrasynaptic glutamate levels sufficiently low to prevent excitotoxic neuronal damage. In GABA synapses hyperactivity of astroglial GABA uptake may lead to diminished GABAergic inhibitory activity resulting in seizures. As a consequence of this the expression and functional activity of astrocytic glutamate and GABA transport is regulated in a number of ways at transcriptional, translational and post-translational levels. This opens for a number of therapeutic strategies by which the efficacy of excitatory and inhibitory neurotransmission may be manipulated. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：521 / 527

页数：7

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