Mapping of quantitative trait loci for ethanol preference in quasi-congenic strains

被引：21

作者：

Vadasz, C

Saito, M

Balla, A

Kiraly, I

Vadasz, C

Gyetvai, B

Mikics, E

Pierson, D

Brown, D

Nelson, JC

机构：

[1] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA

[2] NYU, Med Ctr, New York, NY 10016 USA

[3] New York State Psychiat Inst, Cent Reference Lab, New York, NY 10032 USA

[4] Res Genet Inc, Huntsville, AL 35801 USA

[5] Univ Western Australia, Dept Plant Sci, Nedlands, WA 6907, Australia

来源：

ALCOHOL | 2000年 / 20卷 / 02期

关键词：

alcohol preference; QTL mapping; recombinant QTL introgression; mouse; animal model;

D O I：

10.1016/S0741-8329(99)00068-3

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Ethanol preference, a component of alcoholism, has been known for four decades to differ greatly between C57BL/6 and BALB/c inbred mouse strains. For mapping quantitative trait loci (QTLs) that affect ethanol preference, we used a set of B6.C Recombinant QTL Introgression (RQI) strains, which carry about 5% of the donor BALB/cJ (C) genome on a C57BL/6ByJ (B6) background. After characterizing males of the progenitor and RQI strains for variations in ethanol preference, we scanned their genome for polymorphisms at 244 dinucleotide-repeat marker loci known to differ between B6 and C. Because of the introgression of BALB/c-type QTLs onto the B6 background, some strains showed ethanol preference significantly lower or higher than that of the background strain, suggesting that genetic interaction between ethanol preference QTLs and the background can be operative. The genomic region showing the strongest influence on ethanol preference was on mouse chromosome 15, and corresponds to human chr.12 q11-q13. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：161 / 171

页数：11

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