Are class III and class IX myosins motorized signalling molecules?

被引：41

作者：

Bähler, M ^{[1
]}

机构：

[1] LMU, Adolf Butenandt Inst, D-80336 Munich, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2000年 / 1496卷 / 01期

关键词：

myosin III; myosin IX; protein kinase; Rho; motor molecule; actin; calmodulin; photoreception;

D O I：

10.1016/S0167-4889(00)00008-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Myosins exist that are fused to domains that harbour signalling activities. Class III myosins (NINAC) are protein kinases that play important roles in phototransduction. Class IX myosins inactivate the small G-protein Rho that acts as molecular switch. Because these myosins interact via their myosin head domain with actin filaments, they link signal transduction to the actin cytoskeleton. The exact motor properties of these myosins, however, remain to be determined. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：52 / 59

页数：8

共 45 条

[11] Rho GTPases and the actin cytoskeleton [J].