Skeletal muscle channelopathies

被引：90

作者：

Jurkat-Rott, K

Lerche, H

Lehmann-Horn, F ^{[1
]}

机构：

[1] Univ Ulm, Dept Appl Physiol, D-89069 Ulm, Germany

[2] Univ Ulm, Dept Neurol, D-89069 Ulm, Germany

来源：

JOURNAL OF NEUROLOGY | 2002年 / 249卷 / 11期

关键词：

ionchannels; hereditary diseases; sodium; potassium; calcium chloride;

D O I：

10.1007/s00415-002-0871-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Ion channelopathies have common clinical features, recurrent patterns of mutations, and almost predictable mechanisms of pathogenesis. In skeletal muscle, disorders are associated with mutations in voltage-gated Na+, K+, Ca2+, and Cl- channels leading to hypoexcitability, causing periodic paralysis and to hyperexcitabilty, resulting in myotonia or susceptibility to malignant hyperthermia.

引用

收藏

页码：1493 / 1502

页数：10

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