Carbon nanotube DNA sensor and sensing mechanism

被引：393

作者：

Tang, Xiaowu

Bansaruntip, Sarunya

Nakayama, Nozomi

Yenilmez, Erhan

Chang, Ying-Lan

Wang, Qian

机构：

[1] Univ Waterloo, Dept Chem, Waterloo, ON N2L 3G1, Canada

[2] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

[3] Agilent Technol, Agilent Labs, Palo Alto, CA 94304 USA

来源：

NANO LETTERS | 2006年 / 6卷 / 08期

关键词：

D O I：

10.1021/nl060613v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the fabrication of single-walled carbon nanotube (SWNT) DNA sensors and the sensing mechanism. The simple and generic protocol for label-free detection of DNA hybridization is demonstrated with random sequence 15mer and 30mer oligonucleotides. DNA hybridization on gold electrodes, instead of on SWNT sidewalls, is mainly responsible for the acute electrical conductance change due to the modulation of energy level alignment between SWNT and gold contact. This work provides concrete experimental evidence on the effect of SWNT-DNA binding on DNA functionality, which will help to pave the way for future designing of SWNT biocomplexes for applications in biotechnology in general and also DNA-assisted nanotube manipulation techniques.

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页码：1632 / 1636

页数：5

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