Direct assembly of nucleoside precursors from two- and three-carbon units

被引：74

作者：

Anastasi, Carole ^{[1
]}

Crowe, Michael A. ^{[1
]}

Powner, Matthew W. ^{[1
]}

Sutherland, John D. ^{[1
]}

机构：

[1] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 37期

基金：

英国工程与自然科学研究理事会;

关键词：

carbohydrates; nucleobases; nucleosides; prebiotic chemistry; ribose;

D O I：

10.1002/anie.200601267

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

(Chemical Equation Presented) Sweetness and life: Pentose aminooxazolines - intermediates in potentially prebiotic nucleoside synthesis - can be produced in water from a reaction that bypasses the corresponding sugar. 2-Aminooxazole, a condensation product of glycolaldehyde and cyanamide, reacts with glyceraldehyde under mild conditions in a remarkable process that is essentially quantitative, and is highly stereoselective for ribose and arabinose aminooxazolines. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6176 / 6179

页数：4

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