Gastroprotective effect of a type I arabinogalactan from soybean meal

被引：52

作者：

Cipriani, Thales R. ^{[1
]}

Mellinger, Caroline G. ^{[1
]}

Bertolini, Maria L. C. ^{[1
]}

Baggio, Cristiane H. ^{[2
]}

Freitas, Cristina S. ^{[2
]}

Marques, Maria Consuelo A. ^{[2
]}

Gorin, Philip A. J. ^{[1
]}

Sassaki, Guilherme L. ^{[1
]}

Iacomini, Marcello ^{[1
]}

机构：

[1] Univ Fed Parana, Dept Bioquim & Biol Mol, BR-81531980 Curitiba, Parana, Brazil

[2] Univ Fed Parana, Dept Farmacol, BR-81531980 Curitiba, Parana, Brazil

来源：

FOOD CHEMISTRY | 2009年 / 115卷 / 02期

关键词：

Soybean; Arabinogalactan; Anti-ulcer activity; ANTIULCER POLYSACCHARIDE; MAYTENUS-ILICIFOLIA; PLANTS; PROTECTION; EXTRACT; LEAVES;

D O I：

10.1016/j.foodchem.2008.12.017

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

A highly purified type 1 arabinogalactan (AG) from soybean meal was prepared. It contained galactose. arabinose, galacturonic acid and rhamnose in a 52:41:4:3 molar ratio and had M-w 124,000 g/mol. Methylation analysis and C-13 NMR spectroscopy indicated that AG is constituted by a (1 -> 4)-linked beta-Galp main chain with substituents of alpha-Araf at O-3, which are in turn substituted at O-5, O-3,5, and O-2,5. It is probably linked to O-4 of some rhamnosyl units of a type 1 rhamnogalacturonan, formed by repeating (1 -> 4)-alpha-D-GalpA-(1 -> 2)-alpha-L-Rhap groups. AG significantly inhibited ethanol-induced gastric lesions in rats at an ED50 of 35 mg/kg, indicating that it has a gastroprotective effect. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：687 / 690

页数：4

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