Interferon-γ and colony-stimulating factors as adjuvant therapy for refractory fungal infections in children

被引：76

作者：

Abzug, MJ

Walsh, TJ

机构：

[1] Childrens Hosp, Dept Pediat, Denver, CO 80218 USA

[2] Univ Colorado, Sch Med, Denver, CO 80202 USA

[3] Natl Canc Inst, Immunocompromised Host Sect, Pediat Oncol Branch, Bethesda, MD USA

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2004年 / 23卷 / 08期

关键词：

fungal infection; cytokines; interferon-gamma; colony-stimulating factor; children;

D O I：

10.1097/01.inf.0000134314.65398.bf

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A human immunodeficiency virus-infected boy with Scedosporium apiospermum otomastoiditis and a girl with diabetes mellitus and Mucor sinusitis and orbital cellulitis had life-threatening disease progression despite antifungal treatment. Interferon-gamma and granulocyte-macrophage or granulocyte colony-stimulating factor were added, with good functional outcome in both children. Adjunctive therapy with interferon-gamma, granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor can be considered for refractory invasive fungal infections.

引用

页码：769 / 773

页数：5

共 30 条

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