Bone material properties in trabecular bone from human iliac crest biopsies after 3-and 5-year treatment with risedronate

被引：90

作者：

Durchschlag, Erich

Paschalis, Eleftherios P.

Zoehrer, Ruth

Roschger, Paul

Fratzl, Peter

Recker, Robert

Phipps, Roger

Klaushofer, Klaus

机构：

[1] Hanusch Hosp, Ludwig Boltzmann Inst Osleol, WGKK & AUVA Trauma Ctr Meidling, Med Dept 4, A-1140 Vienna, Austria

[2] Max Planck Inst Colloids & Interfaces, Dept Biomat, Berlin, Germany

[3] Creighton Univ, Osteoporosis Res Ctr, Omaha, NE 68178 USA

[4] Procter & Gamble Pharmaceut, Mason, OH USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2006年 / 21卷 / 10期

关键词：

long-term risedronate treatment; postmenopausal osteoporosis; Fourier transform infrared imaging; mineral maturity/crystallinity; collagen cross-links;

D O I：

10.1359/JBMR.060701

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Long-term effects of risedronate on bone mineral maturity/crystallinity and collagen cross-link ratio in triple iliac crest biopsies of osteoporotic women were evaluated. In this double-blinded study, 3- and 5-year treatment with risedronate arrested the tissue aging encountered in untreated osteoporosis and in osteoporosis treated with other antiresorptives. This effect may be contributing to risedronate's antifracture efficacy.

引用

页码：1581 / 1590

页数：10

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